Endocrine Abstracts

Introduction: Most recent ATA thyroid nodule/DTC guidelines recommend thyroidectomy without prophylactic CND for small (T1 or T2), non-invasive, clinically node-negative PTC (cN0). However, some studies have suggested an association between the BRAFV600E mutation and the risk of nodal disease. Moreover, BRAF V600E mutation have recently showed significant association with recurrence in solitary intrathyroidal PTC between 2 and 4 cm (pT2) making suitable a more aggressive treat...

Introduction: Subclinical hypercortisolism (SH), a condition of biochemical cortisol excess without the classical signs or symptoms of overt hypercortisolism, is thought to be present in the 5–30% of patients with incidentally discovered adrenal mass (adrenal incidentalomas). Some evidence suggest that this condition may lead to long-term consequences of cortisol excess, but indication and potential benefits of adrenalectomy in this state are still in doubt. We analyse a ...

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

TSH level has been proposed as a thyroid malignancy predictor in nodular thyroid disease. In addition, several clinical studies have reported that higher preoperative serum TSH levels were associated with more advanced stages of differentiated thyroid cancer (DTC) at the time of diagnosis.Methods: We collected retrospectively preoperative serum TSH from patients diagnosed of papillary thyroid cancer (PTC) who had undergone total thyroidectomy during the ...

Introduction: The discovery of incidental thyroid carcinomas (ITC) in patients undergoing surgery for a benign disease range between 3 and 16% of cases. During years, patients with hyperthyroidism were considered protected by TSH suppression (TSH is well known factor that favors the development of thyroid cancer). Thyroid size might be a predictive factor due to the excess of thyroid tissue prone to mutations. The knowledge of determining factors foretelling the presence of un...

Autoimmune polyendocrinopathy syndromes (APS) gather a wide range of diseases. The association of autoimmune thyroid disease (ATD) with other organ specific diseases is frequent. Atrophic body gastritis (ABP) is characterized by the loss of ClH and intrinsic factor (IF) production. Both ATD and ABP are known to be associated since 1960 but there are scarce publications describing its clinical features.We review patients with this association selected fro...

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...

The simultaneous occurrence of MTC and PTC in the same thyroid can be observed as a mixed tumour folliculo-medullar (OMS 1988) or as a collision tumour separated by normal thyroid parenchyma, which has only been described in less than thirty patients. We report two cases.Case 1: A 72 years old woman who underwent total thyroidectomy for a multinodular goiter. Histology showed a 2.5 cm CPT in the left lobe and a 4.5 cm CMT in the right lobe. She received ...

Introduction: Abnormal thyroid function is the most common disease in endocrinology and its screening of made by plasmatic (TSH), followed by (fT4) determination if abnormal. (fT3) determination is only used when pathological (TSH) and normal (fT4) are found, even if there is no evidence supporting this procedure, apart from the greater technical difficulty of measuring (fT3) due to its lower plasma concentration.Material and Methods: Observational retro...

Introduction: CCHD comprises a number of different congenital heart defects associated with elevated pulmonary artery pressure and pulmonary vascular resistance, resulting in a reversed or bidirectional shunt (Eisenmenger syndrome). These entities develop systemic hypoxia. Pheochromocytoma and paraganglioma (PHEO/PG) are neuroendocrine tumours. Several inheritance genetic alterations have been reported in PHEO/PG syndromes. A pathogenic association between these entities is pr...